From 2001 to 2004, Cyrus starred in the television show Doc. The show was about a country doctor who moved from Montana to New York City. In late 2005, he also began to co-star in the Disney Channel series Hannah Montana with his daughter Miley Cyrus. The show is currently in its fourth season.

Cyrus was born William Ray Cyrus in Flatwoods, Kentucky to Ron Cyrus, a politician, and his wife, the former Ruth Ann Casto. His grandfather was a Pentecostal preacher. Growing up, he was surrounded by bluegrass and gospel music from his family. His father, a right-handed man, played guitar. Billy Ray, on the other hand, was a lefty. He tried to play his father's guitar, but could never learn. Cyrus attended Georgetown College on a baseball scholarship before switching his focus to music. During the 1980s, Cyrus played in the bar band Sly Dog before getting a record deal with Mercury Nashville Records.

While trying to get a recording contract in Los Angeles, Cyrus was referred to as "too country" for LA, and "too rock" for Nashville. However, in 1990, he was signed to PolyGram/Mercury. Cyrus began to record and write music for his debut album, released in 1992.

Some Gave All was released in 1992. The album became an instant chart and sales successor. It debuted at #1 on the Billboard Top Country Albums, Billboard 200, Canadian Country Albums chart, Canadian Albums Chart, and several other foreign countries. The album featured four consecutive Top 40 singles on the Hot Country Singles & Tracks chart from 1992 to 1993; including an album cut, the title track. The most successful single released was "Achy Breaky Heart". It reached #1 on the Hot Country Singles & Tracks chart and was also a hit on the pop charts, where it reached #4. Although the song was the only number one single, "Could've Been Me" reached #2, "Wher'm I Gonna Live?" reached #23, and "She's Not Cryin' Anymore" reached #6.

Some Gave All was certified 9× Multi-Platinum in the United States in 1996, and has sold over 20 million copies worldwide.

In 1993, Cyrus and Mercury Records quickly released Cyrus' second studio album, It Won't Be the Last. The album featured four singles, however, only three made the Top 40. The album debuted at #1 on the Country charts, and #3 on the Billboard 200. By the end of the year, It Won't Be the Last was certified Platinum by the RIAA. The highest charting single, the lead-off single, "In the Heart of a Woman", charted to #3, with "Somebody New" charting to #9, "Words By Heart" at #12, and "Talk Some" at #63.

Cyrus' third studio album, Storm in the Heartland, was released in 1994. The album was his final album he recorded for PolyGram, as they closed their doors in 1995. The album wasn't as successful as its preceders. It only reached #11 on the Country albums chart, and only the title track made the Top 40 of the Country singles chart. "Deja Blue" was the second single released, however, it only managed to chart to #66, and the third and final single, "One Last Thrill", failed to chart at all.

The album only managed to be certified Gold in the U.S. Before Cyrus started on his next album, he was transferred to Mercury Nashville.

Cyrus' most critically acclaimed album was 1996's, Trail of Tears on Mercury Records. The album debuted at #20 on the Country chart when released. Only two songs made the cut to radio, although neither one hit the Top 60. The title track and "Three Little Words" were released reaching #69, and #65 respectively. The album failed to reach any certification, and was on and off the charts after only four weeks.

Mercury Nashville released Shot Full of Love in 1998. The album became his lowest-peaking album, debuting at #32. The first single, "Under the Hood", failed to chart, "Time for Letting Go" hit #70, "Busy Man" charted #3, and "I Give My Heart to You" reached #41. After the single fell from the charts, Cyrus left Mercury's roster and signed with Monument Records in 1999.